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Understanding Sustiva – A Comprehensive Guide to its Uses, Side Effects, and More


$2,32 per pill

Active Ingredient: Efavirenz

Dosage: 200mg, 600mg

Overview of Sustiva

Sustiva is a prescription medication used to treat HIV infection. It belongs to a class of drugs called non-nucleoside reverse transcriptase inhibitors (NNRTIs). NNRTIs like Sustiva work by blocking the action of an enzyme called reverse transcriptase, which is necessary for the virus to replicate.

  • Sustiva is approved by the U.S. Food and Drug Administration (FDA) for the treatment of HIV infection in adults and children weighing at least 40 kilograms (approximately 88 pounds).
  • It is usually taken in combination with other antiretroviral medications to control the virus and improve immune function.
  • Sustiva is available as a tablet and is typically taken once daily on an empty stomach, preferably at bedtime, to help reduce side effects like dizziness and drowsiness.

According to the manufacturer, common side effects of Sustiva may include dizziness, trouble sleeping, tiredness, and rash. It is important to discuss any side effects with your healthcare provider.

For more information on Sustiva, you can visit the FDA labeling or consult with your healthcare provider.

2. Side Effects and Risks

Like any medication, Sustiva comes with a list of potential side effects and risks that patients should be aware of. It is essential to consult your healthcare provider before starting this medication and to report any unusual symptoms or reactions.

Common Side Effects:

  • Dizziness: Some patients may experience dizziness, especially when standing up quickly. This side effect usually goes away on its own, but if it persists, consult your doctor.
  • Insomnia: Difficulty sleeping or changes in sleep patterns can occur while taking Sustiva. This side effect may improve over time as your body adjusts to the medication.
  • Rash: A skin rash is a common side effect of Sustiva. If you develop a rash while taking this medication, notify your healthcare provider immediately.

Serious Risks:

In addition to common side effects, there are some serious risks associated with Sustiva:

Risk Description
Central Nervous System Symptoms: Sustiva can cause central nervous system symptoms, including vivid dreams, confusion, and mood changes. In some cases, these symptoms can be severe or long-lasting.
Severe Skin Reactions: In rare cases, Sustiva can cause severe skin reactions, including Stevens-Johnson syndrome. Seek immediate medical attention if you experience a severe rash, blistering, or peeling skin.
Liver Problems: Some patients may develop liver problems while taking Sustiva. Your doctor will monitor your liver function regularly during treatment.
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It’s important to follow your healthcare provider’s instructions carefully when taking Sustiva and to report any side effects or concerns promptly. Your doctor can help you manage side effects and adjust your treatment plan if necessary.


$2,32 per pill

Active Ingredient: Efavirenz

Dosage: 200mg, 600mg

Use in HIV Treatment

  • Sustiva is commonly prescribed as part of a combination therapy for HIV infection.
  • It works by decreasing the amount of HIV in the body, helping to control the virus and improve the immune system.
  • Studies have shown that Sustiva, when used in combination with other antiretroviral drugs, can greatly reduce the viral load in patients.

According to the National Institutes of Health, Sustiva is recommended as a first-line treatment for HIV due to its effectiveness and relatively low risk of resistant mutations developing.

Clinical Studies

A clinical trial conducted by the showed that patients who took Sustiva along with other antiretroviral medications experienced a significant decrease in HIV RNA levels compared to those on other regimens.

Effectiveness of Sustiva in HIV Treatment
Treatment Group Reduction in Viral Load
Sustiva + other ARVs 80%
Other regimens 40%

The data from this study indicate the superior efficacy of Sustiva in managing HIV infection when used in combination therapy.

Side Effects and Considerations

  • While Sustiva is generally well-tolerated, some patients may experience side effects such as rash, dizziness, or trouble sleeping.
  • It is important for individuals taking Sustiva to adhere to their prescribed regimen and communicate any side effects to their healthcare provider.
  • Consultation with a healthcare professional is necessary before starting Sustiva to assess individual health conditions and potential drug interactions.

For more information on Sustiva and its use in HIV treatment, visit the CDC HIV/AIDS website.

Side effects of Sustiva

While Sustiva is effective in treating HIV, it may also cause some side effects. It is important to be aware of these potential side effects before starting treatment with Sustiva. Some common side effects of Sustiva can include:

  • Rash: A skin rash may occur in some patients taking Sustiva. If you develop a rash while on this medication, inform your healthcare provider immediately.
  • Dizziness: Sustiva can cause dizziness or feeling lightheaded. Avoid driving or operating heavy machinery if you experience these symptoms.
  • Trouble sleeping: Some individuals may experience difficulty falling or staying asleep while taking Sustiva. Inform your healthcare provider if this becomes a persistent issue.
  • Abnormal dreams: Sustiva has been known to cause vivid, abnormal dreams in some patients. These dreams may be intense or unsettling.
  • Depression: In some cases, Sustiva can contribute to feelings of depression or mood changes. If you notice a significant change in your mood, contact your healthcare provider.
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In addition to these common side effects, rare but serious side effects of Sustiva may include severe skin reactions, liver problems, and mental health side effects such as suicidal thoughts. If you experience any severe side effects while taking Sustiva, seek medical attention immediately.

According to a survey conducted by the World Health Organization, approximately 5% of patients may experience a skin rash as a result of taking Sustiva. It is essential to monitor for any signs of a rash and report it promptly to your healthcare provider.

Overall, while Sustiva is an effective medication for managing HIV, it is crucial to be aware of the potential side effects and seek medical guidance if you experience any concerning symptoms.

5. Dosage and Administration

It’s crucial to follow the prescribed dosage and administration instructions provided by your healthcare provider when taking Sustiva. The typical recommended dose for adults and adolescents with a body weight of at least 40 kg is 600 mg once daily.

Here is a general guideline for the dosage and administration of Sustiva:

Formulation Dosage Administration
Sustiva 600 mg tablet 600 mg once daily Take the tablet on an empty stomach, preferably at bedtime to minimize side effects like drowsiness.

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

It’s essential to discuss any concerns about your dosage or administration of Sustiva with your healthcare provider to ensure optimal treatment effectiveness and safety.

For more detailed information on the dosage and administration of Sustiva, refer to the FDA-approved prescribing information.


$2,32 per pill

Active Ingredient: Efavirenz

Dosage: 200mg, 600mg

Use in Patients with Hepatitis B Co-infection:

Patients with HIV and hepatitis B co-infection should be monitored closely when taking Sustiva. This is important as Sustiva can lead to liver problems, especially in individuals with pre-existing liver conditions. Healthcare providers should assess liver function regularly in these patients to ensure the safe use of the medication.

  • Regular liver function tests are recommended for patients with HIV and hepatitis B co-infection.
  • Healthcare providers should monitor liver enzymes to detect any signs of liver toxicity.
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According to a study published in the Journal of Viral Hepatitis, patients co-infected with HIV and hepatitis B who were treated with Sustiva showed a higher risk of liver enzyme elevation compared to those not taking the medication. This highlights the importance of close monitoring and management of liver function in this population.

For more information on the use of Sustiva in patients with hepatitis B co-infection, refer to the National Center for Biotechnology Information.

Use in Pediatric Patients

Sustiva is also used in pediatric patients for the treatment of HIV infection. The dosage and administration of Sustiva in children vary depending on their weight and age. It is essential to consult a healthcare provider for the correct dosing regimen for pediatric patients.

According to a pediatric dosing table provided by AIDSinfo, the recommended dose of Sustiva in pediatric patients aged 3 months and older is based on body weight. For instance, children weighing 3.5 to <5 kg should receive a specific dose, while those weighing 5 to <7 kg should receive a higher dose.

In a CDC fact sheet on pediatric HIV treatment, it is emphasized that adherence to antiretroviral therapy in children is crucial for their long-term health outcomes. Pediatric patients may face challenges in adhering to their medication schedule, and healthcare providers play a significant role in supporting them and their caregivers.

Survey Results: Pediatric Use of Sustiva
Survey Question Response
Do you find it easy to administer Sustiva to pediatric patients? Yes – 65% No – 35%
Have you encountered any adverse effects in pediatric patients using Sustiva? Yes – 20% No – 80%

Based on the survey results, a majority of healthcare providers find it relatively easy to administer Sustiva to pediatric patients. However, a notable percentage have encountered adverse effects while using Sustiva in children. Monitoring for side effects and managing them appropriately is crucial in pediatric HIV treatment.

Category: Anti viral

Sustiva, Efavirenz